ASUS ProArt X870E-Creator WiFi
Curator note
The cleanest way to run two GPUs on a desktop platform. Its two CPU-attached x16 slots split to x8/x8 when both are filled, and they sit three slots apart, so two dual-slot cards seat directly with a slot of air between them. Enabling the M.2_2 slot drops the second GPU slot to x4, so leave it empty in a two-GPU build. The third x16-length slot runs at x4 from the chipset and is no use for a GPU. AM5 tops out at two GPUs and 256 GB of memory; for more, step up to Threadripper or EPYC.
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